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KMID : 0381219920240010026
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Journal of RIMSK
1992 Volume.24 No. 1 p.26 ~ p.32
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A Study on Inhibitory Effect of Topical Nonsteroidal Anti-inflammatory Agents to Prostaglandin before and after Anterior Chamber Paracentesis in Rabbits
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Abstract
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Increased prostaglandin in anterior chamber has been known as a factor of miosis, increasing intraocular pressure and postoperative inflammation caused by the destruction of blood-aqueous barrier.
In our study, we used 1% tropicamide and 10% Phenylephrine 30 minutes before anterior chamber paracentesis for pupillary dilatation and the pupillary diameters were measured just before and 30 minutes after paracentesis.
For the purpose of comparing the anti-inflammatory affects of antiprostaglandin agents as Aspegic(r), Profenal(r) we also used the above topical agents 90 minutes before and after anterior chamber paracentesis in 20 rabbits(40 eyes).
The degree of anti-inflammatory effect was assessed by measuring Prostaglandin E2 and total protein amounts in the first and second aspirated humor.
The inhibitory effects of pupillary constriction were significantly greater (P<0.05) in Aspegic(r), Profenal(r), Ocufen(r) than control and the lowering effects of Prostaglandin E2 and total protein in anterior chamber were also greater(p<0.05)
in
Aspegic(r), Ocufen(r), than control. Among them, Profenal(r) had more potent effect.
We could conclude prostaglandin may be one of the important mediator of ocular inflammation after intraocular surgery. The topical non-steroidal anti-inflammatory agents can inhibit the PG activator in anterior chamber and interrupt the miosis
during
surgery and rising intraocular pressure after operation.
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